The position is placed at the Faculty of Health and Society, Department of Biomedical Science. The education and research activities comprised by the faculty aim at contributing to the knowledge base in order to preserve, support and promote people’s physical, psychological, and social health. Research is taking place in areas ranging from science, technology and medicine to social science. At the interfaces between them, exciting new areas for research are being generated. The research at the faculty is also linked to the research programme Biofilms - Research Center for Biointerfaces which combines research with medical, dental, food and environmental applications, at three of our faculties, in close collaboration with regional industry.
Job description and responsibilities
The core question for the overall project is “How to achieve topical quantification of low molecular weight endogenous compounds for monitoring skin-disorder progression and healing?” To succeed with this enterprise Malmö University has teamed up with seven industry partners; Chemotechnique Diagnostics AB, Bioglan AB, in Vitro Plant-tech AB, ImaGene-iT AB, Medibiome AB, Scibase AB and Chromalytica AB, who share a genuine interest in skin related applications. Thus, the results of the project will have an immediate impact in industry and quicker return of the investment for modernizing healthcare.
A limiting factor in the development of non-invasive devices for detection of skin disorders is the restricted access to skin disease biomarkers. Biopsies are used today because the diagnostic decision is based on analysis of high molecular weight (HMW) biomarkers, e.g., cytokines or cell surface receptors. Since HMW biomarkers do not leak to the skin surface, these biomarkers cannot be used for non-invasive detection. However, although skin is a tough biological barrier, it allows diffusion of low molecular weight (LMW) compounds (< 500 Da). Thus, we hypothesize that it is feasible to achieve robust non-invasive or minimally invasive monitoring of skin disorders by monitoring LMW biomarkers. Particularly, we aim to develop monitoring of LMW biomarkers of inflammation and cancer. The proposed approach will be studied using skin membranes in-vitro and validated using cell cultures. Highly specific assays for LMW biomarkers in skin-derived cells will be developed. We will test in vitro-cultured skin cells for LMW biomarker generation and HMW biomarker expression by using HPLC-MS, fluorescent microscopy, flow cytometry, and ELISA. For glycoprotein biomarker detection we will use molecularly imprinted polymers (MIP)-based methods. By comparing, HMW biomarker expression vs LMW biomarker generation the LMW biomarker approach to monitor skin disorders will be validated. We will also analyze the influence of the different components in the plant extracts on inflammatory and cancer development processes in cell cultures. The candidate for this postdoc position is expected to perform relevant experiments, supervise the experimental work of others, present the results in form of manuscripts, as well as establish relevant collaborations with the other members of the project.
Apart from carrying out research within the mentioned areas the applicant is expected to take responsibility for the maintenance of the instruments involved and to be active by supervising postgraduate students and fellow scientists in the techniques, as well as participate in teaching at post-graduate and graduate level. Teaching at undergraduate level may also to some extent be required. In addition, the applicant should (when applicable) be responsible for contacts on operational level with involved industry partners.
Required Qualifications and Criteria for Assessment of Applicants
Candidates must be cell biologists by training and have a doctoral degree (not more than five years before the last date for this application) together with a good track record in the field of molecular biology, cell biology and biomedical laboratory science. Experience in handling of cell cultures and assessment of clinical samples, as well as immunological methods are necessary. Special considerations will be given to scientific expertise in and previous hands-on experience in more than one of the following methods: immunohistochemistry, optical measurements, cell separation and imaging. Documented excellent level of English (understanding, speaking and writing) is essential. The candidate should also have the ability to work in a team and collaborate with people in complementary disciplines. Previous experience from working in research projects that involved both industry and academia is highly valued.
Form of employment and starting date
Temporary position, starting September 2017
Anette Gjörloff Wingren, Professor in biomedical laboratory sciencePhone: +46 70 6011857, Mail: email@example.com
Tautgirdas Ruzgas, Professor in Biomedical technology Phone: +46 40 66 57431, Mail: firstname.lastname@example.org
Johan Engblom, Professor in Biomedical technology Phone: +46 40 665 74 83, Mail: email@example.com
Instructions to Applicants
You apply through Malmö Universities’ recruitment system by clicking the button “ansök”. It is your own responsibility that your application is complete with all required documentation according to the adverted position. Your application must have arrived no later than August 15th, 2017.
The application should contain the following:
- A brief summary of scientific, teaching and other qualifications relevant to the position
- Attested copies of certificates
- Signed list of qualifications (CV)
- List of scientific publications
- Copies of three of your most relevant scientific publications
Trade union representatives
SACO, Ann-Mari Campbell tel: 040-665 74 37
OFR/Lärarförbundet, Peter Persson tel:040-665 82 76
OFR/S (ST) Naser Eftekharian tel: 040-665 76 49